Contact an Account Manager1-Hexyl-3-methyl imidazolium tetrafluoroborate: An efficient column enhancer for the separation of basic drugs by reversed-phase liquid chromatography
Summary
Type: HPLC
Application #: 126120
Catalog#: 720120.46 - MN HPLC Column, Nucleosil C18, 100A, 5um, 4.6x150mm
Detection:
Conditions: Eluent (Zorbax, without ionic liquid): acetonitrile – water (15.8:84.2, v/v), pH 3 (adjusted with 0.01 mol/L citric acid monohydrate + sodium hydroxide)
Eluent (Zorbax, with ionic liquid): acetonitrile – 0.0232 mol/L HMIM BF4 in water (10.0:90.0, v/v), pH 3 (adjusted with 0.01 mol/L citric acid monohydrate + sodium hydroxide)
Eluent (NUCLEOSIL, without ionic liquid): acetonitrile – water (18.1:81,9, v/v), pH 3 (adjusted with 0.01 mol/L citric acid monohydrate + sodium hydroxide)
Eluent (NUCLEOSIL, with ionic liquid): acetonitrile – 0.0244 mol/L HMIM BF4 in water (10.0:90.0, v/v), pH 3 (adjusted with 0.01 mol/L citric acid monohydrate + sodium hydroxide)
Flow rate: 1 mL/min (recommended)
HMIM BF4 = 1-hexyl-3-methyl imidazolium tetrafluoroborate
Authors: Fernández-Navarro et al.
Source: J. Chromatogr. A 1258 (2012) 168–174